Cagrilintide

Description

Cagrilintide — Long-Acting Amylin Receptor Agonist Peptide

Cagrilintide is a synthetic long-acting analogue of human amylin, engineered as an agonist acting at the amylin receptor. It is produced by solid-phase synthesis and supplied for in vitro laboratory research use only.

Research context

Published preclinical literature has examined cagrilintide’s binding affinity and cAMP-signalling activity at the amylin receptor (AMY) family in transfected cell-line systems, distinguishing amylin-receptor activation from calcitonin-receptor background signalling. Receptor-pharmacology studies have also examined its combination with GLP-1 receptor agonist peptides as a combined-agonist model for dual-pathway signal-transduction research. Functional cAMP-accumulation and receptor-binding assays remain the primary in vitro methods applied to this compound. Structural-stability studies have additionally examined engineered modifications that reduce the fibrillation propensity characteristic of native amylin, using biophysical aggregation assays relevant to in vitro handling, alongside circular-dichroism studies of secondary-structure stability under varied buffer conditions and storage-temperature regimes relevant to lyophilised-powder handling.

Specification

• Available sizes: 2mg · 5mg · 10mg
• Form: lyophilised powder
• Purity: ≥99% (HPLC)
• Testing: independently lot-tested by Horizon Analytical · Certificate of Analysis per lot

For laboratory research use only. This material is supplied to qualified researchers and institutions for in vitro investigational use. It is not a drug, food, cosmetic or medical device. It is not intended for human or veterinary use, for diagnosis, treatment, cure or prevention of any disease, or for any use outside a controlled laboratory environment. No statement on this site has been evaluated by the Food and Drug Administration. Keep out of reach of children.

Related Research

Compound family: Cagrisema (2.5mg + 2.5mg), Cagrisema (5mg + 5mg), Cagrisema (10mg + 10mg), Semaglutide

Browse: Metabolic Research · All Research Peptides

Reconstitution & Lab Testing: All products independently tested by Horizon Analytical. See our Reconstitution & Lab Testing FAQ. Reconstitution typically requires BAC Water.