Eloralintide

Description

Eloralintide — Selective AMY1R Amylin Receptor Agonist Peptide

Eloralintide is a synthetic, lipidated 37-residue analogue of human amylin, engineered as a selective agonist acting at the AMY1R amylin receptor subtype. It is supplied for in vitro laboratory research use only.

Research context

Published cAMP-activation assay literature reports eloralintide to be approximately 11-fold more potent at AMY1R than at AMY3R, and approximately 12-fold more potent at AMY1R than at the calcitonin receptor, in transfected receptor-expressing cell-line systems — a receptor-selectivity profile distinct from non-selective amylin-receptor analogues. Structural studies describe a methylene thioacetal bridge between Cys2 and Cys7 in place of the native disulfide bond, together with three non-coded residues at positions 11, 15 and 22, intended to produce a molecule suited to reproducible in vitro handling. A gamma-Glu-gamma-Glu-C20 diacid side chain at Lys26 has been characterised as driving albumin-binding behaviour relevant to plasma protein-binding assay design. These structural and pharmacological characteristics have been examined using cAMP-based functional assays in cell lines individually engineered to express each amylin-receptor subtype.

Specification

• Available sizes: 10mg · 20mg
• Form: lyophilised powder
• Purity: ≥99% (HPLC)
• Testing: independently lot-tested by Horizon Analytical · Certificate of Analysis per lot

For laboratory research use only. This material is supplied to qualified researchers and institutions for in vitro investigational use. It is not a drug, food, cosmetic or medical device. It is not intended for human or veterinary use, for diagnosis, treatment, cure or prevention of any disease, or for any use outside a controlled laboratory environment. No statement on this site has been evaluated by the Food and Drug Administration. Keep out of reach of children.

Related Research

Compound family: Cagrilintide, Cagrisema (2.5mg + 2.5mg), Cagrisema (5mg + 5mg), Cagrisema (10mg + 10mg)

Browse: Metabolic Research · All Research Peptides

Reconstitution & Lab Testing: All products independently tested by Horizon Analytical. See our Reconstitution & Lab Testing FAQ. Reconstitution typically requires BAC Water.