Liraglutide

Description

Liraglutide — Acylated GLP-1 Receptor Agonist Peptide

Liraglutide is a synthetic acylated analogue of GLP-1, engineered with a fatty-acid side chain to extend plasma protein-binding, acting as an agonist at the GLP-1 receptor. It is supplied for in vitro laboratory research use only.

Research context

Published literature has examined liraglutide’s binding affinity and cAMP-accumulation activity at the GLP-1 receptor in transfected cell-line systems, including pancreatic beta-cell line model systems used to characterise receptor-mediated signal transduction. Structure-activity studies have examined the C16 fatty-acid acylation that confers extended plasma albumin-binding and altered proteolytic-degradation kinetics relative to native GLP-1. Receptor-binding and functional cAMP-signalling assays remain the primary in vitro methodologies applied to this compound in the literature. Receptor-internalisation and desensitisation assays in transfected cell lines have additionally been used to characterise prolonged receptor-occupancy behaviour associated with the acylated structure, using fluorescence-based receptor-trafficking assay formats in transfected reporter cell lines.

Specification

• Available sizes: 5mg · 10mg · 30mg
• Form: lyophilised powder
• Purity: ≥99% (HPLC)
• Testing: independently lot-tested by Horizon Analytical · Certificate of Analysis per lot

For laboratory research use only. This material is supplied to qualified researchers and institutions for in vitro investigational use. It is not a drug, food, cosmetic or medical device. It is not intended for human or veterinary use, for diagnosis, treatment, cure or prevention of any disease, or for any use outside a controlled laboratory environment. No statement on this site has been evaluated by the Food and Drug Administration. Keep out of reach of children.

Related Research

Compound family: Retatrutide, Tirzepatide, Semaglutide, Dulaglutide

Browse: Metabolic Research · All Research Peptides

Reconstitution & Lab Testing: All products independently tested by Horizon Analytical. See our Reconstitution & Lab Testing FAQ. Reconstitution typically requires BAC Water.