Dulaglutide

Description

Dulaglutide — GLP-1 Receptor Agonist Fusion Protein

Dulaglutide is a synthetic long-acting fusion protein linking two GLP-1 receptor agonist peptide analogues to a modified human IgG4 heavy-chain fragment. It is supplied for in vitro laboratory research use only.

Research context

Published literature has examined dulaglutide’s binding affinity and cAMP-accumulation activity at the GLP-1 receptor in transfected cell-line systems, including pancreatic beta-cell line model systems used to characterise receptor-mediated signal transduction. Structure-function studies have examined how the IgG4 fusion architecture affects plasma protein-binding behaviour and receptor-binding kinetics relative to non-fusion GLP-1 receptor agonist peptides. Receptor-binding and functional cAMP-signalling assays remain the primary in vitro methodologies applied to this compound. Analytical characterisation work has further examined the glycosylation pattern of the Fc fragment and its relationship to receptor-binding reproducibility across production lots, using mass-spectrometry-based glycan profiling and comparative receptor-binding assay panels run across sequential independent production lots over time.

Specification

• Available sizes: 5mg · 10mg
• Form: lyophilised powder
• Purity: ≥99% (HPLC)
• Testing: independently lot-tested by Horizon Analytical · Certificate of Analysis per lot

For laboratory research use only. This material is supplied to qualified researchers and institutions for in vitro investigational use. It is not a drug, food, cosmetic or medical device. It is not intended for human or veterinary use, for diagnosis, treatment, cure or prevention of any disease, or for any use outside a controlled laboratory environment. No statement on this site has been evaluated by the Food and Drug Administration. Keep out of reach of children.

Related Research

Compound family: Retatrutide, Tirzepatide, Semaglutide, Liraglutide

Browse: Metabolic Research · All Research Peptides

Reconstitution & Lab Testing: All products independently tested by Horizon Analytical. See our Reconstitution & Lab Testing FAQ. Reconstitution typically requires BAC Water.