PE-22-28

Description

PE-22-28 — Spadin-Derived Peptide Fragment

PE-22-28 is a seven-amino-acid derivative of the spadin peptide, supplied for in vitro laboratory research only.

Research context

Preclinical literature has examined PE-22-28 as a selective antagonist of the TREK-1 (K2P2.1) two-pore-domain potassium channel. Investigators use it in ion-channel electrophysiology assays, hippocampal cell-culture models, and rodent behavioural-pharmacology model systems examining BDNF expression and synaptic signalling downstream of channel blockade. Reported study designs include patch-clamp recordings characterising channel conductance, quantitative PCR and immunohistochemical analysis of hippocampal BDNF expression, and receptor-binding assays comparing selectivity against related two-pore-domain potassium channel subtypes. As a shortened spadin derivative, PE-22-28 is also referenced in comparative ion-channel pharmacology literature alongside related two-pore-domain potassium channel ligands, with additional study designs pairing chromatographic stability analysis with gene-expression profiling of hippocampal synaptic-plasticity markers across multiple rodent brain-slice preparations.

Specification

• Available sizes: 10mg
• Form: lyophilised powder
• Purity: ≥99% (HPLC)
• Testing: independently lot-tested by Horizon Analytical · Certificate of Analysis per lot

For laboratory research use only. This material is supplied to qualified researchers and institutions for in vitro investigational use. It is not a drug, food, cosmetic or medical device. It is not intended for human or veterinary use, for diagnosis, treatment, cure or prevention of any disease, or for any use outside a controlled laboratory environment. No statement on this site has been evaluated by the Food and Drug Administration. Keep out of reach of children.

Related Research

Compound family: Semax, Selank, Cerebrolysin, Cortagen

Browse: Neuropeptide Research · All Research Peptides

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