ARA-290

Description

ARA-290 (Cibinetide) — Erythropoietin-Derived Undecapeptide

ARA-290, also known as Cibinetide, is an 11-amino-acid peptide derived from the three-dimensional structure of erythropoietin, supplied for in vitro laboratory research only.

Research context

Preclinical literature has examined ARA-290 as a selective ligand of the heteromeric erythropoietin receptor/CD131 complex — referred to in the literature as the innate repair receptor (IRR) — which is structurally and functionally distinct from the homodimeric erythropoietin receptor responsible for erythropoiesis. Investigators use it in cell-based receptor-binding assays and in vitro models of small-fibre neuronal signalling and cytokine-pathway modulation, frequently applying competitive radioligand-binding assays to distinguish IRR-selective activity from classical erythropoietin-receptor activation. Reported study designs include electrophysiological recordings of peripheral sensory-neuron cultures and gene-expression analyses of cytokine-signalling intermediates in immune and neuronal cell lines. As the lead compound in a broader class of erythropoietin-derived, non-erythropoietic peptide fragments, ARA-290 is also referenced in comparative receptor-pharmacology literature examining structure-activity relationships across EPO-derived helix-B fragment analogues.

Specification

• Available sizes: 10mg · 16mg
• Form: lyophilised powder
• Purity: ≥99% (HPLC)
• Testing: independently lot-tested by Horizon Analytical · Certificate of Analysis per lot

For laboratory research use only. This material is supplied to qualified researchers and institutions for in vitro investigational use. It is not a drug, food, cosmetic or medical device. It is not intended for human or veterinary use, for diagnosis, treatment, cure or prevention of any disease, or for any use outside a controlled laboratory environment. No statement on this site has been evaluated by the Food and Drug Administration. Keep out of reach of children.

Related Research

Compound family: Humanin, Semax, Cortagen, Cardiogen

Browse: Neuropeptide Research · All Research Peptides

Reconstitution & Lab Testing: All products independently tested by Horizon Analytical. See our Reconstitution & Lab Testing FAQ. Reconstitution typically requires BAC Water.