SLU-PP-322

Description

SLU-PP-322 — Synthetic ERRα/β/γ Agonist Small Molecule

SLU-PP-322 is a synthetic small-molecule agonist acting at the estrogen-related receptor (ERR) family — ERRα, ERRβ and ERRγ. It is supplied for in vitro laboratory research use only.

Research context

Published biochemical literature has examined SLU-PP-322’s binding affinity at ERRα/β/γ and its downstream effect on transcriptional activation of genes governing mitochondrial biogenesis and fatty-acid oxidation enzyme pathways, using transfected reporter cell-line assays. In vitro studies in skeletal-muscle cell-culture models have examined shifts in oxidative-fibre gene-expression markers following receptor activation. Transcriptional-reporter and gene-expression assays remain the primary in vitro methodologies applied to this compound in the published literature. Receptor-selectivity studies using radiolabelled-ligand displacement across the three ERR subtypes have further characterised its relative binding affinity for each isoform, with dose-response curve fitting applied to derive comparative potency values in each individual cell-line model across multiple independent assay replicates performed on separate days.

Specification

• Available sizes: 5mg
• Form: lyophilised powder
• Purity: ≥99% (HPLC)
• Testing: independently lot-tested by Horizon Analytical · Certificate of Analysis per lot

For laboratory research use only. This material is supplied to qualified researchers and institutions for in vitro investigational use. It is not a drug, food, cosmetic or medical device. It is not intended for human or veterinary use, for diagnosis, treatment, cure or prevention of any disease, or for any use outside a controlled laboratory environment. No statement on this site has been evaluated by the Food and Drug Administration. Keep out of reach of children.

Related Research

Compound family: 5-AMINO-1MQ, Adipotide (FTPP), AICAR, AOD9604

Browse: Metabolic Research · All Research Peptides

Reconstitution & Lab Testing: All products independently tested by Horizon Analytical. See our Reconstitution & Lab Testing FAQ. Reconstitution typically requires BAC Water.